Current treatment options for ALS

21 Bekeken

TAKE ACTION

Donations would go to support charities for How-To & Style

In How-To & Style

This video presents the therapeutics currently available for the treatment and management of amyotrophic lateral sclerosis (ALS). It describes the pathophysiology of ALS as well as the progression of the disease. It examines the symptoms of ALS. It then discusses the two-pronged treatment approach that includes the prescription of pharmaceuticals that slow the progression of ALS, and the management of symptoms through various symptom-directed therapies. Finally, the video looks at stem-cell based therapies that are in development for the treatment of ALS.

This video was made by McMaster Demystifying Medicine students Lulu Faidi, Sandeep Ghotra, Stephanie Gagnon and Abhinaya Garlapati

Copyright McMaster University 2018

To learn more about ALS, visit the Canada ALS Society at www.als.ca

References:

1.Kiernan MC, Vucic S, Cheah BC, Turner MR, Eisen A, Hardiman O, Burrell JR, Zoing MC. Amyotrophic lateral sclerosis. The Lancet. 2011;377(9769):942-55.

2.ALSA.org. (2018). What is ALS?. [online] Available at: http://www.alsa.org/about-als/....what-is-als.htmlhttp [Accessed 7 Nov. 2018].

3.Galvin M, Gaffney R, Corr B, Mays I, Hardiman O. From first symptoms to diagnosis of amyotrophic lateral sclerosis: perspectives of an Irish informal caregiver cohort—a thematic analysis. BMJ open. 2017 Mar 1;7(3):e014985.

4. Dharmadasa T, Kiernan MC. Riluzole, disease stage and survival in ALS. The Lancet Neurology. 2018;17(5):385-6.

5.Yeo CJ, Simmons Z. Discussing edaravone with the ALS patient: an ethical framework from a US perspective. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 2018;19(3-4):167-72.

6.Phukan J, Hardiman O. The management of amyotrophic lateral sclerosis. Journal of Neurology.2009;256(2):176.

7.Amyotrophic lateral sclerosis (ALS) - Diagnosis and treatment - Mayo Clinic [Internet]. Mayoclinic.org. 2018 [cited 4 November 2018]. Available from: https://www.mayoclinic.org/dis....eases-conditions/amy

8.Lunn JS, Sakowski SA, Feldman EL. Concise review: Stem cell therapies for amyotrophic lateral sclerosis: recent advances and prospects for the future. Stem Cells. 2014;32(5):1099-109.

9.Forostyak S, Sykova E. Neuroprotective potential of cell-based therapies in ALS: from bench to bedside. Frontiers in Neuroscience.2017;11:591.