Youmanitarian 10 Jun 2021

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HIV - AIDS - Sign, Symptoms, Transmission and Treatment

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HIV - AIDS - Symptoms and Treatment

1. Introduction to HIV/AIDS.
2. Detailed explanation on Retrovirus.
3. Epidemiology of AIDS.
4. Structure of HIV virus.
a) Structure of envelop.
b) Different CD4+ cells.
c) Interaction between GP120 and CD4+ cells.
5. Clinical aspects of GP120 and CCR5.
6. How HIV will produce AIDs and genetics of CCR5 in HIV resistance.
7. Genetic variations in GP120 due to which antidote for HIV has not developed yet.
8. Important features of GP120 molecule and its clinical aspects.
9. Attachment inhibitor and fusion inhibitor drugs.
10. ENV gene and envelop proteins.
11. Location and function of matrix proteins (p-17).
12. Location, composition of capsid and its clinical important (p-24).
13. RNA dimers and Positive polarity RNA v/s negative polarity RNA.
14. Important enzymes and their functions.
(a) Reverse transcriptase.
(b) Integrase.
(c) Protease.
15. Some major differences between HIV1 and HIV2 .
16. Nucleocapsid proteins and their clinical importance.
17. Important genes and their functions.
(1) GAG gene (2) POL gene (3) ENV gene
18. Introduction to Replication cycle and genomic variety.
19. Structure of virus.
20. HIV entry into CD4+ cells.
21. Replication inside cytoplasm
(a) Dissolution of capsid.
(b) Activity of Reverse transcriptase.
(c) Integrase activity and formation of pro-viral DNA.
(b)Clinical importance of integrase activity.
22. Drugs that inhibit enzymatic activity during replication.
(a) Attachment inhibitor and fusion inhibitor drugs.
(b) Nucleotide/nucleoside reverse transcriptase inhibitor.
(c) Non-Nucleotide/nucleoside reverse transcriptase inhibitor.
(d) Integrase inhibitor.
23. Structure of viral genome.
(a) Long terminal repeats (promoter region & transcription factors).
(b) Structural genes ( GAG, POL and ENV genes).
(c) Concept of reading frames and formation of regulatory proteins from structural genes.
24. Defense system of HIV.
25. Budding of HIV.